Strangers in Paradise is the story of best friends Francine and Katchoo. Francine is the shy, kind hearted one, while Katchoo was always the wild girl at school who got into trouble but didn't care. (In the picture Francine has dark hair, Katchoo is the blonde.)
Now Francine and Katchoo are sharing a house and we start the story with Francine in love with a guy who treats her like rubbish. Katchoo is in love with Francine and has been since high school, and while Katchoo is at the gallery she meets David who falls in love with her.
The story sounds like an average romantic comedy, but Moore develops it into a moving look at life and love, and this being a comic there is room for adventure and suspense. Especially when Katchoo's shady and violent past starts to catch up with her. This series won many awards and praise but I'll let comic legend Neil Gaiman have the final word, "what most people don't know about love, sex, and relations with other human beings would fill a book. Strangers in Paradise is that book." Couldn't have put it better myself.